Influence of co-morbidity on renal function assessment by Cockcroft-Gault calculation in lung cancer and mesothelioma patients receiving platinum-based chemotherapy.

@article{Hubner2011InfluenceOC,
  title={Influence of co-morbidity on renal function assessment by Cockcroft-Gault calculation in lung cancer and mesothelioma patients receiving platinum-based chemotherapy.},
  author={Richard A. Hubner and Robyn Goldstein and Sandy Mitchell and Arthur John Jones and S. C. Ashley and Mary R O'Brien and Sanjay Popat},
  journal={Lung cancer},
  year={2011},
  volume={73 3},
  pages={356-60}
}
BACKGROUND Creatinine clearance (CrCl) estimation by Cockcroft-Gault calculation (CG) often replaces measurement of glomerular filtration rate (GFR) by [(51)Cr]-ethylenediaminetetraacetic acid clearance (EDTA). Co-morbidity, age, and renal impairment influence the accuracy of CG, whilst the relationship between CG and EDTA has been poorly assessed in lung cancer patients, a population significantly affected by these covariates. METHODS Retrospective analysis of co-morbidity, nephrotoxic drug… CONTINUE READING