Influence of cis-diamminedichloroplatinum(II) on DNA synthesis and cell cycle progression in excision repair proficient and deficient Chinese hamster ovary cells.

@article{Sorenson1988InfluenceOC,
  title={Influence of cis-diamminedichloroplatinum(II) on DNA synthesis and cell cycle progression in excision repair proficient and deficient Chinese hamster ovary cells.},
  author={C M Sorenson and A. Eastman},
  journal={Cancer research},
  year={1988},
  volume={48 23},
  pages={6703-7}
}
DNA has been implicated as the critical intracellular target for cis-diamminedichloroplatinum(II) (cis-DDP) action. Inhibition of DNA synthesis is a consequence of platination and has become accepted as the critical step in cis-DDP-induced toxicity. We have previously demonstrated that, following incubation with cis-DDP, murine leukemia L1210 cells progress through synthesis only to arrest in the G2 phase of the cell cycle. The G2 arrest was transient at low drug concentrations and was… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 62 extracted citations

Molecular pathways: the immunogenic effects of platinum-based chemotherapeutics.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2014

Similar Papers

Loading similar papers…