Influence of circadian time, ageing, and hypertension on the urinary excretion of nitric oxide metabolites in rats.

@article{Borgonio1999InfluenceOC,
  title={Influence of circadian time, ageing, and hypertension on the urinary excretion of nitric oxide metabolites in rats.},
  author={A Borgonio and Klaus Witte and Raoul Stahrenberg and Bjoern Lemmer},
  journal={Mechanisms of ageing and development},
  year={1999},
  volume={111 1},
  pages={23-37}
}
Urinary excretion of NO metabolites (NOx) was measured in male spontaneously hypertensive rats (SHR) and their normotensive Wistar-Kyoto controls (WKY) in two age groups: young (11 weeks) and old (58 weeks). Urine was collected every 6 h throughout 24 h with and without injection interperitoneally of N(G)-nitro-L-arginine-methyl-ester (L-NAME), 30 mg/kg, at 7:00 or 19:00 h. In addition, blood pressure changes by L-NAME were evaluated using radiotelemetry. In both strains of rats, injection of L… CONTINUE READING

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