Influence of cimetidine on the pharmacokinetics of piroxicam in rat and man.

@article{Said1989InfluenceOC,
  title={Influence of cimetidine on the pharmacokinetics of piroxicam in rat and man.},
  author={Shehta Abd-Allah Said and A M Foda},
  journal={Arzneimittel-Forschung},
  year={1989},
  volume={39 7},
  pages={790-2}
}
The influence of cimetidine on piroxicam plasma levels and pharmacokinetic parameters was studied in both rats and healthy volunteers. In male rats, intravenous injection of piroxicam (6 mg/kg) in animals pretreated with cimetidine (50 mg/kg intramuscular) resulted in plasma piroxicam concentrations significantly higher than those of animals which received piroxicam alone. The plasma half-life (1/2) of piroxicam in male rats was about 8.3 h and it was increased to 20.74 h by cimetidine… CONTINUE READING

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