Influence of cigarette smoking on pemphigus – a systematic review and pooled analysis of the literature

  title={Influence of cigarette smoking on pemphigus – a systematic review and pooled analysis of the literature},
  author={Olivia Lai and Andreas Recke and Detlef Zillikens and Michael Kasperkiewicz},
  journal={Journal of the European Academy of Dermatology and Venereology},
Epidemiological evidence suggests that smoking cigarettes may be beneficial in pemphigus, but no systematic evaluation exists to corroborate this assumption. Therefore, a systematic literature review with pooled data analysis of the smoking status in patients with pemphigus was conducted. Electronic searches using PubMed from inception to November 2017 identified 13 reports meeting predetermined inclusion and exclusion criteria. Most were case–control studies partly reporting that pemphigus… 
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Pemphigus vulgaris is a chronic autoimmune bullous dermatosis that results from the production of autoantibodies against desmogleins 1 and 3, and recent studies have shown a beneficial effect of rituximab, an anti-CD20 immunobiological drug.
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The real great discoveries leading to progress with paradigmchanging impact are usually published in basic science journals like Science, Nature or Journal of Experimental Medicine – as it was the
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Pemphigus in Israel--an epidemiologic analysis of cases in search of risk factors.
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Pemphigus and depression comorbidity: a case control study
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Bipolar Disorder Associated with Another Autoimmune Disease—Pemphigus: A Population-based Study
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First results indicate that nonsteroidal treatment of pemphigus is possible and cholinomimetic Mestinon may be used to slow down progression of the disease and to treat mild cases with chronic lesions on limited areas.
Impact of smoking on pemphigus
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