Influence of chronic cigarette smoke exposure on the uptake and efflux of imipramine in the isolated perfused rat lung.

Abstract

The pulmonary uptake and efflux of imipramine was determined in lungs removed from cigarette smoke-exposed and nonexposed rats. Using an isolated perfused lung preparation, the lung was perfused for 220 sec with medium containing 2.5 X 10(-7) M imipramine, followed by a 28-min drug-free perfusion. There was no significant difference (p less than 0.05… (More)

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@article{Hunter1983InfluenceOC, title={Influence of chronic cigarette smoke exposure on the uptake and efflux of imipramine in the isolated perfused rat lung.}, author={Eric Hunter and Steven Sloneker and H. B. Kostenbauder}, journal={Drug metabolism and disposition: the biological fate of chemicals}, year={1983}, volume={11 4}, pages={361-5} }