Influence of chromatin and single strand binding proteins on the activity of an archaeal MCM.

@article{Marsh2006InfluenceOC,
  title={Influence of chromatin and single strand binding proteins on the activity of an archaeal MCM.},
  author={Victoria L Marsh and Adam T. McGeoch and Stephen D Bell},
  journal={Journal of molecular biology},
  year={2006},
  volume={357 5},
  pages={
          1345-50
        }
}
The mini-chromosome maintenance (MCM) complex is the presumptive replicative helicase in archaea and eukaryotes. In archaea, the MCM is a homo-multimer, in eukaryotes a heterohexamer composed of six related subunits, MCM 2-7. Biochemical studies using naked DNA templates have revealed that archaeal MCMs and a sub-complex of eukaryotic MCM 4, 6 and 7 have 3' to 5' helicase activity. Here, we investigate the influence of the major chromatin proteins, Alba and Sul7d, of Sulfolobus solfataricus… CONTINUE READING

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