Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene.


CONTEXT Genetic inheritance and developmental life stress both contribute to major depressive disorder in adults. Child abuse and trauma alter the endogenous stress response, principally corticotropin-releasing hormone and its downstream effectors, suggesting that a gene x environment interaction at this locus may be important in depression. OBJECTIVE To… (More)
DOI: 10.1001/archgenpsychiatry.2007.26


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