Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene.

Abstract

CONTEXT Genetic inheritance and developmental life stress both contribute to major depressive disorder in adults. Child abuse and trauma alter the endogenous stress response, principally corticotropin-releasing hormone and its downstream effectors, suggesting that a gene x environment interaction at this locus may be important in depression. OBJECTIVE To… (More)
DOI: 10.1001/archgenpsychiatry.2007.26

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