Influence of changes in the concentration of sex hormone-binding globulin in human serum on the protein binding of the contraceptive steroids levonorgestrel, 3-keto-desogestrel and gestodene.

@article{Kuhnz1994InfluenceOC,
  title={Influence of changes in the concentration of sex hormone-binding globulin in human serum on the protein binding of the contraceptive steroids levonorgestrel, 3-keto-desogestrel and gestodene.},
  author={Wilhelm Kuhnz and Burkhardt Siegfried Sch{\"u}tt and R Woloszczak},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={1994},
  volume={48 5-6},
  pages={573-80}
}
The serum protein binding of levonorgestrel, gestodene and 3-keto-desogestrel has been determined during several clinical studies with different oral contraceptive formulations and one in vitro study. The results of these studies were combined in order to assess the relation between changes in the concentration of sex hormone-binding globulin (SHBG) and the effect on the free fraction of the progestins as well as on their distribution with respect to the binding proteins albumin and SHBG… CONTINUE READING