Influence of cerebrovascular resistance on the dynamic relationship between blood pressure and cerebral blood flow in humans.

@article{Smirl2014InfluenceOC,
  title={Influence of cerebrovascular resistance on the dynamic relationship between blood pressure and cerebral blood flow in humans.},
  author={Jonathan D. Smirl and Y C Tzeng and Bradley J. Monteleone and Philip N. Ainslie},
  journal={Journal of applied physiology},
  year={2014},
  volume={116 12},
  pages={
          1614-22
        }
}
We examined the hypothesis that changes in the cerebrovascular resistance index (CVRi), independent of blood pressure (BP), will influence the dynamic relationship between BP and cerebral blood flow in humans. We altered CVRi with (via controlled hyperventilation) and without [via indomethacin (INDO, 1.2 mg/kg)] changes in PaCO2. Sixteen subjects (12 men, 27 ± 7 yr) were tested on two occasions (INDO and hypocapnia) separated by >48 h. Each test incorporated seated rest (5 min), followed by… CONTINUE READING

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