Influence of cations on the complexation yield of DOTATATE with yttrium and lutetium: a perspective study for enhancing the 90Y and 177Lu labeling conditions.

@article{Asti2012InfluenceOC,
  title={Influence of cations on the complexation yield of DOTATATE with yttrium and lutetium: a perspective study for enhancing the 90Y and 177Lu labeling conditions.},
  author={Mattia Asti and Matteo Tegoni and Daniela Farioli and Michele Iori and Claudio Guidotti and Cathy Sue Cutler and Pat Mayer and Annibale Versari and Diana Salvo},
  journal={Nuclear medicine and biology},
  year={2012},
  volume={39 4},
  pages={509-17}
}
The DOTA macrocyclic ligand can form stable complexes with many cations besides yttrium and lutetium. For this reason, the presence of competing cationic metals in yttrium-90 and lutetium-177 chloride solutions can dramatically influence the radiolabeling yield. The aim of this study was to evaluate the coordination yield of yttrium- and lutetium-DOTATATE complexes when the reaction is performed in the presence of varying amounts of competing cationic impurities. In the first set of experiments… CONTINUE READING