Influence of carnosine on the cardiotoxicity of doxorubicin in rabbits.
@article{Zieba2003InfluenceOC, title={Influence of carnosine on the cardiotoxicity of doxorubicin in rabbits.}, author={Remigiusz Zieba and Malgorzata Wagrowska-Danilewicz}, journal={Polish journal of pharmacology}, year={2003}, volume={55 6}, pages={ 1079-87 } }
The aim of this study was to establish the effect of naturally occurring antioxidant carnosine (CAR) on the doxorubicin (DOX)-induced cardiotoxicity in a rabbit model. For this purpose, we evaluated the influence of DOX administration alone and in a combined therapy with CAR on the hemodynamic parameters and on the degree of cardiac muscle cell alterations in rabbits. Thirty one chinchilla rabbits were divided into four groups. One group of rabbits was injected iv with DOX at a dose of 2 mg kg…
21 Citations
Amifostine improves hemodynamic parameters in doxorubicin-pretreated rabbits.
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It is shown that pretreatment with doxorubicin at the total dose of 12 mg/kg significantly reduced CI and increased TPR in doxorbicin-pretreated rabbits, and amifostine improved CI and TPR on average in these animals.
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An increase in oxidative stress, superoxide dismutase, glutathione peroxidase levels, catalase inactivation and cardiac dysfunction induced by adriamycin were prevented by carnosine.
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The results may indicate that CAR alone, especially in combination with Vit E, protect against DOX-induced toxicity in heart, liver, and kidney tissues of rats.
Therapeutic effect of carnosine in rat model of experimental liver carcinogenesis.
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Effects of oral administration of orodispersible levo-carnosine on quality of life and exercise performance in patients with chronic heart failure.
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The newly developed 2-aminomethylphenol class of scavengers shows great promise in preclinical trials for a number of diverse conditions including neurodegenerative diseases and cardiovascular disease and new studies with the thiol-based and imidazole-based scavengers have found new applications outside of adjunctive therapy for chemotherapeutics.
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