Influence of carnosine on the cardiotoxicity of doxorubicin in rabbits.

  title={Influence of carnosine on the cardiotoxicity of doxorubicin in rabbits.},
  author={Remigiusz Zieba and Malgorzata Wagrowska-Danilewicz},
  journal={Polish journal of pharmacology},
  volume={55 6},
The aim of this study was to establish the effect of naturally occurring antioxidant carnosine (CAR) on the doxorubicin (DOX)-induced cardiotoxicity in a rabbit model. For this purpose, we evaluated the influence of DOX administration alone and in a combined therapy with CAR on the hemodynamic parameters and on the degree of cardiac muscle cell alterations in rabbits. Thirty one chinchilla rabbits were divided into four groups. One group of rabbits was injected iv with DOX at a dose of 2 mg kg… CONTINUE READING
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Cardiac toxicity in cancer therapy ( Polish )

  • A. YoungbergG.
  • Pol . Merkuriusz Lek
  • 2002

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