Influence of carboxylesterase 2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients.

@article{Fujiyama2009InfluenceOC,
  title={Influence of carboxylesterase 2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients.},
  author={Nobuhiro Fujiyama and Masatomo Miura and Shigeru Satoh and Kazuyuki Inoue and Hideaki Kagaya and Mitsuru Saito and Tomonori Habuchi and Toshio Suzuki},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={2009},
  volume={39 5},
  pages={407-14}
}
Mycophenolic acid (MPA), converted from the prodrug mycophenolate mofetil (MMF), is generated by intestinal and hepatic esterases. The role of carboxylesterase (CES) in MMF hydrolysis was examined in vitro using human liver microsomes. V(max) and K(m) values of MMF hydrolysis in pooled human liver microsomes were 1368 +/- 44 nmol min(-1) mg(-1) protein and… CONTINUE READING