Influence of captopril on the cellular uptake and toxic potential of microcystin-LR in non-hepatic adhesive cell lines.

@article{Teneva2016InfluenceOC,
  title={Influence of captopril on the cellular uptake and toxic potential of microcystin-LR in non-hepatic adhesive cell lines.},
  author={Ivanka Teneva and Dorota Klaczkowska and Tsvetelina G Batsalova and Zhivka Kostova and Balik M Dzhambazov},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2016},
  volume={111},
  pages={50-7}
}
Microcystin-LR (MC-LR) is a toxin produced by various cyanobacterial strains. Its cytotoxicity is due to inhibition of the protein phosphatases PP1 and PP2A, resulting in hyperphosphorylation of a number of functional and cytoskeletal proteins. To penetrate through the plasma membrane, MC-LR needs specific transporters such the organic anion-transporting… CONTINUE READING