Influence of calcium-sensing receptor gene on urinary calcium excretion in stone-forming patients.

@article{Vezzoli2002InfluenceOC,
  title={Influence of calcium-sensing receptor gene on urinary calcium excretion in stone-forming patients.},
  author={Giuseppe Vezzoli and Annalisa Tanini and Luigi Ferrucci and Laura Soldati and Cristiana Bianchin and Francesco Franceschelli and Cecilia Malentacchi and Berardino Porfirio and Donatella Adamo and Annalisa Terranegra and Alberto Falchetti and Daniele Cusi and Giuseppe Bianchi and Maria Luisa Brandi},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2002},
  volume={13 10},
  pages={2517-23}
}
Calcium-sensing receptor (CaSR) is a plasma membrane protein that regulates tubular reabsorption of Ca. To establish its role in idiopathic hypercalciuria, the association of urinary Ca excretion with the polymorphisms of CASR gene has been studied in healthy subjects and in hypercalciuric and normocalciuric Ca stone formers. CASR exon 7 single nucleotide polymorphisms (SNP), G/T at codon 986, G/A at codon 990, and C/G at codon 1011, were evaluated by PCR amplification and direct sequencing in… CONTINUE READING
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