Influence of blood proteins on biomedical analysis. IX. Protective effects of human serum proteins on anion-induced degradation of gliclazide.

@article{Kobayashi1986InfluenceOB,
  title={Influence of blood proteins on biomedical analysis. IX. Protective effects of human serum proteins on anion-induced degradation of gliclazide.},
  author={K. Kobayashi and Ayumi Igaki and Masako Kimura and T Sakoguchi and Mitsuko Shimosawa and Akira Matsuoka},
  journal={Chemical \& pharmaceutical bulletin},
  year={1986},
  volume={34 7},
  pages={
          2957-62
        }
}
Gliclazide, 1-(3-azabicyclo[3.3.0]oct-3-yl)-3-(p-tolylsulfonyl)urea, an oral hypoglycemic drug having the sulfonylurea structure, was completely degraded in a medium containing more than 0.2M chloride or bromide ion at 37°C after 24h. Other sulfonylureas, tolazamide and glycopyramide, were also degraded in the presence of chloride ion, but tolbutamide, acetohexamide, chlorpropamide and glibenclamide were not. Fluoride, carbonate, acetate, sulfate and phosphate ions and both sodium and potassium… 
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