Influence of beta-adrenoceptor agonists and antagonists on baclofen-induced memory impairment in mice.

Abstract

Post-training administration of different doses of baclofen (a GABAB agonist) has been shown to impair memory retention, in a step-down passive avoidance test in mice. We have studied the effects of beta-adrenergic agonists and antagonists on baclofen-induced memory impairment in mice. Dobutamine (a beta 1-agonist) or salbutamol (a beta 2-agonist) reversed the memory impairment induced by baclofen without exhibiting intrinsic actions on memory when administered alone. The administration of atenolol (a beta 1-antagonist) or propranolol (a beta-antagonist) produced a memory impairment. When co-administered with baclofen, both atenolol and propranolol exacerbated the memory impairment induced by the GABAB agonist. It is concluded that beta-adrenergic mechanisms may be involved in the modulation of memory via GABAB receptors.

Cite this paper

@article{Zarrindast2004InfluenceOB, title={Influence of beta-adrenoceptor agonists and antagonists on baclofen-induced memory impairment in mice.}, author={Mohammad Reza Zarrindast and Homa Haidari and Mohammad Reza Jafari and Bijan Djahanguiri}, journal={Behavioural pharmacology}, year={2004}, volume={15 4}, pages={293-7} }