Influence of bestatin on production of granulocyte-macrophage colony-stimulating factor from human peripheral blood mononuclear cells in vitro.

Abstract

Bestatin, (25, 3R)-3-amino-2-hydroxy-4-phenylbutyryl-L-leucine, enhanced proliferation of normal human bone marrow granulocyte-macrophage progenitor cells to form CFU-GM colonies in viscous methylcellulose medium in vitro. To elucidate the mechanisms of this effect, the levels of colony-stimulating factor (CSF) in culture supernatant of 1 x 10(6)/ml… (More)

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@article{Okamura1990InfluenceOB, title={Influence of bestatin on production of granulocyte-macrophage colony-stimulating factor from human peripheral blood mononuclear cells in vitro.}, author={S. Okamura and Fusayuki Omori and Kazunori Haga and Hiroshi Baba and Kumiko Sugimachi and Yoshiyuki Niho}, journal={Acta oncologica}, year={1990}, volume={29 6}, pages={795-7} }