Influence of benzodiazepine binding site ligands on fear-conditioned contextual memory.

@article{Delorey2001InfluenceOB,
  title={Influence of benzodiazepine binding site ligands on fear-conditioned contextual memory.},
  author={Timothy M Delorey and R. S. Lin and B McBrady and Xiaohui He and James M Cook and Jelveh Lameh and Gilda H. Loew},
  journal={European journal of pharmacology},
  year={2001},
  volume={426 1-2},
  pages={45-54}
}
Eight compounds that bind to the benzodiazepine binding site on the gamma-amino butyric acid(A) (GABA(A)) receptor were assessed for their influence on contextual memory, an aspect of memory affected in various cognitive disorders including Alzheimer's disease. Using a Pavlovian fear-conditioning paradigm, each ligand was evaluated in C57Bl/6 mice in regards to its direct affect on contextual memory and whether the ligand could attenuate scopolamine-induced contextual memory impairment. Of the… CONTINUE READING
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