Influence of baseline variables on changes in International Prostate Symptom Score after combined therapy with dutasteride plus tamsulosin or either monotherapy in patients with benign prostatic hyperplasia and lower urinary tract symptoms: 4‐year results of the CombAT study

@article{Roehrborn2014InfluenceOB,
  title={Influence of baseline variables on changes in International Prostate Symptom Score after combined therapy with dutasteride plus tamsulosin or either monotherapy in patients with benign prostatic hyperplasia and lower urinary tract symptoms: 4‐year results of the CombAT study},
  author={Claus G. Roehrborn and Jack Barkin and Andrea Tubaro and Mark Emberton and Timothy H. Wilson and Betsy Brotherton and Ramiro Castro},
  journal={BJU International},
  year={2014},
  volume={113}
}
To examine, using post hoc analysis, the influence of baseline variables on changes in international prostate symptom score (IPSS), maximum urinary flow rate (Qmax) and IPSS quality of life (QoL) in patients with moderate‐to‐severe lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) treated with either the α‐blocker tamsulosin or the dual 5‐alpha reductase inhibitor dutasteride, alone or in combination, as part of the 4‐year Combination of Avodart and Tamsulosin… 
Model‐based meta‐analysis of the time to first acute urinary retention or benign prostatic hyperplasia‐related surgery in patients with moderate or severe symptoms
TLDR
This work aimed to disentangle the contribution of clinical and demographic baseline characteristics affecting the risk of acute urinary retention or BPH‐related surgery (AUR/S) from the effect of treatment with drugs showing symptomatic and disease‐modifying properties.
Model‐based meta‐analysis of individual International Prostate Symptom Score trajectories in patients with benign prostatic hyperplasia with moderate or severe symptoms
TLDR
The current investigation aimed to develop a drug‐disease model to describe individual IPSS trajectories in moderate and severe BPH patients.
Impact of early vs. delayed initiation of dutasteride/tamsulosin combination therapy on the risk of acute urinary retention or BPH-related surgery in LUTS/BPH patients with moderate-to-severe symptoms at risk of disease progression
TLDR
Start of CT before month 6 appears to significantly reduce the risk of AUR/S compared with delayed start by ≥ 6 months, which has implications for the treatment algorithm for men with LUTS/BPH at risk of disease progression.
Prospective comparison of tadalafil 5 mg alone, silodosin 8 mg alone, and the combination of both in treatment of lower urinary tract symptoms related to benign prostatic hyperplasia
TLDR
Tadalafil and silodosin are effective treatment options in men with BPH who have LUTS, but the combination of both is more effective and feasible in treating LUTs of BPH.
Clinical significance of prostatic-urethral angulation on the treatment outcome of patients with symptomatic benign prostatic hyperplasia treated with tamsulosin hydrochloride.
  • H. El-Tatawy, T. Gameel, K. Abudewan
  • Medicine
    Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica
  • 2015
TLDR
Tamsulosin hydrochloride appears to be less effective in improving IPSS/Qol score, Qmax and PVR in patients with lager PUA, and might be a predictor for the treatment efficacy of α-blockers.
Medical treatment of lower urinary tract symptoms/benign prostatic hyperplasia: anything new in 2015
TLDR
The recent literature refines the knowledge on current therapeutic options and provides further evidence for an individualized, risk-adapted approach for male LUTS mainly depending on symptoms status, comorbidities and risk of disease progression.
Comparing Clinical and Economic Outcomes Associated with Early Initiation of Combination Therapy of an Alpha Blocker and Dutasteride or Finasteride in Men with Benign Prostatic Hyperplasia in the United States.
TLDR
Clinical and economic outcomes were similar among BPH patients treated with early continuous combination AB and 5ARI therapy and early dutasteride + AB cohorts, with no statistically significant differences detected.
...
...

References

SHOWING 1-10 OF 19 REFERENCES
The long-term effect of doxazosin, finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasia.
TLDR
Long-term combination therapy with doxazosin and finasteride was safe and reduced the risk of overall clinical progression of benign prostatic hyperplasia significantly more than did treatment with either drug alone.
Clinical outcomes after combined therapy with dutasteride plus tamsulosin or either monotherapy in men with benign prostatic hyperplasia (BPH) by baseline characteristics: 4‐year results from the randomized, double‐blind Combination of Avodart and Tamsulosin (CombAT) trial
TLDR
It’s shown that direct hits to the immune system are more likely to be associated with dementia than other types of injuries, including gunshot wounds and strokes.
Discontinuation of Alpha-Blockade after Initial Treatment with Finasteride and Doxazosin for Bladder Outlet Obstruction
TLDR
Patients with symptomatic bladder outlet obstruction and moderately enlarged prostates who are placed initially on combination therapy using finasteride and an α-blocker are likely to tolerate discontinuation of the α- blocker after 9 months of combination therapy.
...
...