Influence of asimadoline, a new kappa-opioid receptor agonist, on tubular water absorption and vasopressin secretion in man.

@article{Kramer2000InfluenceOA,
  title={Influence of asimadoline, a new kappa-opioid receptor agonist, on tubular water absorption and vasopressin secretion in man.},
  author={H. Kramer and W. Uhl and B. Ladstetter and A. Baecker},
  journal={British journal of clinical pharmacology},
  year={2000},
  volume={50 3},
  pages={
          227-35
        }
}
  • H. Kramer, W. Uhl, +1 author A. Baecker
  • Published 2000
  • Chemistry, Medicine
  • British journal of clinical pharmacology
  • AIMS The purpose of the study was to investigate the effects of asimadoline, a new kappa-opioid agonist, on renal function and on hormones related to body fluid balance as well as its tolerability in healthy subjects. METHODS In a placebo-controlled, randomised, double-blind crossover design we studied the effects of single oral doses of 1, 5, and 10 mg of asimadoline, in 24 healthy volunteers. Two hour control urine collections were followed by 2 h postdose urine collections and subsequently… CONTINUE READING
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