Influence of artificial fat emulsions on the composition of serum lipoproteins in humans.

  title={Influence of artificial fat emulsions on the composition of serum lipoproteins in humans.},
  author={Susanne Hailer and G{\"u}nther Wolfram},
  journal={The American journal of clinical nutrition},
  volume={43 2},
  • S. Hailer, G. Wolfram
  • Published 1 February 1986
  • Medicine
  • The American journal of clinical nutrition
Infusions of about 50 g soya oil, emulsified with egg lecithin (Intralipid) or soya lecithin (Lipofundin) have different effects on the composition of serum lipoprotein fractions in volunteers (n = 6). Triglycerides are altered in all lipoprotein fractions most in lowest density classes but also in LDL and HDL. Differences in maximal concentrations (higher during Intralipid) and differences in removal rate of triglycerides (faster with Lipofundin) are due to different emulsifiers. Cholesterol… 
Effect of fat-emulsion phospholipids on serum lipoprotein profile during 1 mo of cyclic total parenteral nutrition.
It is suggested that changes in serum lipoprotein determined by selective precipitation were induced by the twofold-higher intake of phospholipids in group A, and administration of 20% IL seems preferable to 10% IL.
Influence of Different Fat Emulsions with 10 or 20% MCT/LCT or LCT on Lipoproteins in Plasma of Patients after Abdominal Surgery
In patients after elective abdominal surgery, different fat emulsions were used to compare their efficacy in total parenteral nutrition and in normalizing plasma lipoprotein levels and this fat emulsion is suggested as having the best normalizing effect on plasma lipiproteins and best tolerance in patients after surgery.
Changes in serum lipoproteins in humans following the infusion of a fat emulsion containing medium‐ and long‐chain triglycerides
High density lipoprotein (HDL) subfractions are influenced in identical directions by all fat emulsions with exception of a single increase of phospholipids in ( HDL3) after Lipofundin MCT.
Acute and chronic effects of a 24-hour intravenous triglyceride emulsion challenge on plasma lecithin: cholesterol acyltransferase, phospholipid transfer protein, and cholesteryl ester transfer protein activities.
Plasma LCAT, PLTP, and CETP activity levels are stimulated by a large intravenous fat load, but the time course of their responses and the effects of insulin coadministration are different.
Phospholipid-rich particles in commercial parenteral fat emulsions. An overview.
It is interesting to note that patients on prolonged TPN, in particular those with a short small intestine, have weak cholesterolemia, reflecting a lowering of HDL and LDL not masked by elevated LP-X, and it seems difficult to produce sufficiently stable parenteral EMU devoid of PLRP.
Alteration of erythrocyte lipid composition following total parenteral nutrition in the rat.
  • S. Innis
  • Biology, Medicine
    JPEN. Journal of parenteral and enteral nutrition
  • 1989
Compared to sham-operated rats fed chow, the erythrocyte membranes from rats given TPN with lipid emulsion had increased cholesterol and PL but normal molar cholesterol:PL ratios and suggested replacement of endogenous PL with the exogenous egg PL infused with the emulsion.
Plasma lipoprotein pattern during long-term home parenteral nutrition with two lipid emulsions.
Although no change was observed in plasma lipid concentration of baseline samples during 3 months of home parenteral nutrition, some modifications were observed in the composition of lipoprotein fractions demonstrating a redistribution of lipid components.
Serum lipoprotein changes after prolonged intralipid infusion in malnourished haemodialysis patients.
After prolonged lipid infusion, the apoprotein B and C-II increased suggesting a triglyceride transport activation and Lipoprotein A-I decreased in each case (p < 0.005), suggesting a reduction of its related risk of atherogenesis.
Lack of accumulation of midazolam in plasma and lipoprotein fractions during intravenous lipid infusions in patients on artificial respiration
The data show for the first time that a significant increase in plasma triglycerides during an intravenous lipid infusion does not result in accumulation of midazolam in lipoproteins, probably because albumin binding of the drug is very strong.