Influence of arterial hypoxia on cardiac and coronary dynamics in the conscious sinoaortic-denervated dog.

@article{Krasney1977InfluenceOA,
  title={Influence of arterial hypoxia on cardiac and coronary dynamics in the conscious sinoaortic-denervated dog.},
  author={John A Krasney and Raymond C Koehler},
  journal={Journal of applied physiology: respiratory, environmental and exercise physiology},
  year={1977},
  volume={43 6},
  pages={1012-8}
}
Arterial hypoxia was produced in 10 conscious, chronically instrumented, tracheostomized dogs by allowing them to breathe 7.5% O2 in N2 for 10 min. Hypoxia (Pao2 = 28 +/- 0.7 (SE) Torr) caused significant increases in coronary blood flow (+196%), left ventricular dP/dt max (+60%), aortic blood flow (+48%), heart rate (+50%), and left ventricular systolic… CONTINUE READING