Influence of apolipoprotein E genotype on neuronal damage and apoE immunoreactivity in human hippocampus following global ischemia.

@article{Horsburgh1999InfluenceOA,
  title={Influence of apolipoprotein E genotype on neuronal damage and apoE immunoreactivity in human hippocampus following global ischemia.},
  author={Karen J Horsburgh and David I. Graham and Janice Stewart and James A. R. Nicoll},
  journal={Journal of neuropathology and experimental neurology},
  year={1999},
  volume={58 3},
  pages={227-34}
}
Apolipoprotein E (apoE) influences the response to and outcome from brain injury possibly through alterations in neuronal repair mechanisms. This study aimed to determine alterations in neuronal and glial apoE after brain injury in patients and sought to determine whether possession of an apoE-epsilon4 allele influences the degree of apoE immunoreactivity or the degree of neuronal damage following brain injury. ApoE immunoreactivity and neuronal damage were semiquantitatively assessed in the… CONTINUE READING