Influence of apoA-V gene variants on postprandial triglyceride metabolism: impact of gender.

Abstract

Although apolipoprotein A-V (apoA-V) polymorphisms have been consistently associated with fasting triglyceride (TG) levels, their impact on postprandial lipemia remains relatively unknown. In this study, we investigate the impact of two common apoA-V polymorphisms (-1131 T>C and S19W) and apoA-V haplotypes on fasting and postprandial lipid metabolism in adults in the United Kingdom (n = 259). Compared with the wild-type TT, apoA-V -1131 TC heterozygotes had 15% (P = 0.057) and 21% (P = 0.002) higher fasting TG and postprandial TG area under the curve (AUC), respectively. Significant (P = 0.038) and nearly significant (P = 0.057) gender x genotype interactions were observed for fasting TG and TG AUC, with a greater impact of genotype in males. Lower HDL-cholesterol was associated with the rare TC genotype (P = 0.047). Significant linkage disequilibrium was found between the apoA-V -1131 T>C and the apoC-III 3238 C>G variants, with univariate analysis indicating an impact of this apoC-III single nucleotide polymorphism (SNP) on TG AUC (P = 0.015). However, in linear regression analysis, a significant independent association with TG AUC (P = 0.007) was only evident for the apoA-V -1131 T>C SNP, indicating a greater relative importance of the apoA-V genotype.

DOI: 10.1194/jlr.M700112-JLR200

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@article{OlanoMartn2008InfluenceOA, title={Influence of apoA-V gene variants on postprandial triglyceride metabolism: impact of gender.}, author={Est{\'i}baliz Olano-Mart{\'i}n and Elizheeba Christie Abraham and Rosalynn D Gill-Garrison and Ana M Valdes and Keith A. Grimaldi and Fiona Tang and Kim Jackson and Christine M. Williams and Anne Marie Minihane}, journal={Journal of lipid research}, year={2008}, volume={49 5}, pages={945-53} }