Influence of anticancer agents on cell survival, proliferation, and CD4+CD25+Foxp3+ regulatory T cell-frequency in human peripheral-blood mononuclear cells activated by T cell-mitogen.

@article{Tohyama2013InfluenceOA,
  title={Influence of anticancer agents on cell survival, proliferation, and CD4+CD25+Foxp3+ regulatory T cell-frequency in human peripheral-blood mononuclear cells activated by T cell-mitogen.},
  author={Naoya Tohyama and Sachiko Tanaka and Kenji Onda and Kentaro Sugiyama and Toshihiko Hirano},
  journal={International immunopharmacology},
  year={2013},
  volume={15 1},
  pages={160-6}
}
Many anticancer agents currently used are considered to be cytotoxic not only to cancer cells but also to functional immune cells. To learn more about the immunosuppressive adverse influence of chemotherapeutic drugs in cancer chemotherapy, we examined the effects of arsenic trioxide, dacarbazine, 5-fluorouracil, and methotrexate on the survival, proliferation, cytokine production, and CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) cell-frequency in human peripheral blood mononuclear cells (PBMCs… CONTINUE READING

Citations

Publications citing this paper.

References

Publications referenced by this paper.
Showing 1-10 of 28 references

5-Fluorouracil derivatives: a patent review.

Expert opinion on therapeutic patents • 2012
View 1 Excerpt

Foxp 3 exploits a pre - existent enhancer landscape for regulatory T cell lineage speci fi cation

RK Samstein, A Arvey, +3 authors S Neph
2012

Impaired IFN-a production by plasmacytoid dendritic cells favors regulatory T cell expansion and contributes to breast cancer progression

V Sisirak, J Faget, +3 authors I Treilleux
Cancer Res Jul • 2012
View 2 Excerpts

Regulatory T-cells: diverse phenotypes integral to immune homeostasis and suppression

RA Peterson
Toxicol Pathol • 2012
View 1 Excerpt

Similar Papers

Loading similar papers…