Influence of anti-Nogo-A antibody treatment on the reorganization of callosal connectivity of the premotor cortical areas following unilateral lesion of primary motor cortex (M1) in adult macaque monkeys

@inproceedings{Hamadjida2012InfluenceOA,
  title={Influence of anti-Nogo-A antibody treatment on the reorganization of callosal connectivity of the premotor cortical areas following unilateral lesion of primary motor cortex (M1) in adult macaque monkeys},
  author={Adjia Hamadjida and Alexander F. Wyss and Anis Khusro Mir and Martin E. Schwab and Abderaouf Belhaj-Saif and Eric M. Rouiller},
  booktitle={Experimental Brain Research},
  year={2012}
}
Following unilateral lesion of the primary motor cortex, the reorganization of callosal projections from the intact hemisphere to the ipsilesional premotor cortex (PM) was investigated in 7 adult macaque monkeys, in absence of treatment (control; n = 4) or treated with function blocking antibodies against the neurite growth inhibitory protein Nogo-A (n = 3). After functional recovery, though incomplete, the tracer biotinylated dextran amine (BDA) was injected in the ipsilesional PM… CONTINUE READING