Influence of amodiaquine treatment on microsomal lipid peroxidation and antioxidant defense systems of rats.

@article{Farombi2000InfluenceOA,
  title={Influence of amodiaquine treatment on microsomal lipid peroxidation and antioxidant defense systems of rats.},
  author={Ebenezer O. Farombi},
  journal={Pharmacology \& toxicology},
  year={2000},
  volume={87 6},
  pages={
          249-54
        }
}
  • E. O. Farombi
  • Published 1 December 2000
  • Chemistry, Medicine
  • Pharmacology & toxicology
The effects of single and multiple doses amodiaquine treatment on enzymatic and non-enzymatic antioxidant profiles and hepatic microsomal lipid peroxidation were investigated in rats. Treatment of rats with 10 mg/kg (single dose) amodiaquine resulted in 10% and 63% increases, respectively in the activities of liver superoxide dismutase and glutathione peroxidase (P<0.01), while the activity of liver catalase was significantly reduced by 26% compared to control. The levels of serum vitamins A, C… 
Antioxidant status and hepatic lipid peroxidation in chloramphenicol-treated rats.
  • E. O. Farombi
  • Chemistry, Medicine
    The Tohoku journal of experimental medicine
  • 2001
TLDR
The results of the present investigation indicate alteration of enzymatic and nonenzymatic antioxidant status and induction of lipid peroxidation by chloramphenicol, and the clinical implications in the detoxification of toxic metabolites of lipidPeroxidation caused by chlorampshenicol warrant co-administration with antioxidant vitamins in chlorampenicol treatment regimen.
Sulphadoxine-pyrimethamine alters the antioxidant defense system in blood of rabbit.
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