Influence of amodiaquine on the antimalarial activity of ellagic acid: crystallographic and biological studies.

@article{esawska2014InfluenceOA,
  title={Influence of amodiaquine on the antimalarial activity of ellagic acid: crystallographic and biological studies.},
  author={Ewa Żesławska and Barbara J. Oleksyn and Aude Fabre and Françoise Benoit-Vical},
  journal={Chemical biology & drug design},
  year={2014},
  volume={84 6},
  pages={669-75}
}
In the search for new antimalarial drugs, design of hybrid molecules is recommended to improve biological activity and to decrease the risk of parasite resistance development. Ellagic acid, as an inhibitor of Plasmodium glutathione, presents an original mode of action and thus appears as a promising antiplasmodial compound. A new complex (AQ-EA) consisting… CONTINUE READING