Influence of ambient temperature on the development and maintenance of tolerance to ethanol-induced hypothermia.


The development of tolerance to the hypothermic effect of ethanol was examined during chronic ethanol treatment (5 g/kg PO daily) at various ambient temperatures (Ta). Tolerance to the hypothermic effect of ethanol, monitored at five-day intervals for 25 days, developed rapidly when ethanol treatment was carried out at 4 degrees C. On the other hand, rats… (More)


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