Influence of alprazolam on opioid analgesia and side effects during steady-state morphine infusions.

@article{Coda1992InfluenceOA,
  title={Influence of alprazolam on opioid analgesia and side effects during steady-state morphine infusions.},
  author={Barbara Coda and Alan M Mackie and Harlan F. Hill},
  journal={Pain},
  year={1992},
  volume={50 3},
  pages={309-16}
}
The primary purpose of this study was to examine whether alprazolam pretreatment can increase the analgesic potency of morphine without increasing opioid side-effect intensities. We employed computer-controlled, variable-rate morphine infusions based on each subject's pharmacokinetic profile for morphine derived from a tailoring bolus dose of the drug administered 1 or 2 weeks before the infusion test sessions. On each of 2 test days, we used dental electrical stimulation to determine stimulus… CONTINUE READING