Influence of alpha-melanocyte-stimulating hormone and ultraviolet radiation on the transfer of melanosomes to keratinocytes.

@article{Virador2002InfluenceOA,
  title={Influence of alpha-melanocyte-stimulating hormone and ultraviolet radiation on the transfer of melanosomes to keratinocytes.},
  author={Victoria M. Virador and Jacqueline Muller and Xufneg Wu and Zalfa A Abdel-Malek and Z Yu and V{\'i}ctor J. Ferrans and Nobuhiko Kobayashi and Kazumasa Wakamatsu and Shosuke Ito and John A Hammer and Vincent J. Hearing},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2002},
  volume={16 1},
  pages={105-7}
}
The epidermal melanin unit in human skin is composed of melanocytes and keratinocytes. Melanocytes, located in the basal layer of the epidermis, manufacture melanin-loaded organelles called melanosomes. Through their dendritic processes, melanocytes distribute melanosomes to neighboring keratinocytes, where their presence confers to the skin its characteristic color and photoprotective properties. In this study, we used murine melanocytes and keratinocytes alone and in coculture to characterize… CONTINUE READING