Influence of alpha-chloralose on muscle relaxant effect of chlorzoxazone in rats and pharmacodynamic analysis.

@article{Kaneko1989InfluenceOA,
  title={Influence of alpha-chloralose on muscle relaxant effect of chlorzoxazone in rats and pharmacodynamic analysis.},
  author={I Kaneko and Yoshinobu Fukumori and Tomoaki Fukuda and Yoshikazu Takeuchi},
  journal={Journal of pharmacobio-dynamics},
  year={1989},
  volume={12 8},
  pages={
          441-7
        }
}
The Pharmacological response intensity of chlorzoxazone (CZX) was measured by the crossed extensor reflex (CER) method in anesthetized rats. The appropriate dose of alpha-chloralose (ACH) was examined to bring about a quantitative effect of CZX. The pharmacodynamics of CZX was also characterized in the anesthetized rats at three different doses of CZX. When rats were anesthetized with ACH at three different doses (80, 110, and 150 mg/kg i.p.), the CER response caused by CZX at the doses of 25… 
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Effect of alpha-chloralose on disposition and pharmacological action of orally administered chlorzoxazone in rats.
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The pharmacodynamic behavior of orally administered chlorzoxazone (CZX) was studied in rats and it was found that CZX obeyed a one-compartment model with first-order absorption, suggesting that the pharmacokinetic and pharmacodynamic concept proposed by Smolen was not applicable to CZX's behavior at such a dose in rats.
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