Influence of allelic variations of hypoxia-related and DNA repair genes on patient outcome and toxicity in head and neck cancer treated with radiotherapy plus cetuximab

Abstract

Although cetuximab plus radiotherapy is a standard treatment for patients with inoperable head and neck squamous cell carcinoma (HNSCC), its efficacy varies greatly among individuals. To identify predictive markers of efficacy, we examined the effects of single nucleotide polymorphisms (SNPs) in hypoxia-related and DNA repair genes on the clinical outcome… (More)
DOI: 10.1007/s00405-015-3740-4

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@article{Muoz2015InfluenceOA, title={Influence of allelic variations of hypoxia-related and DNA repair genes on patient outcome and toxicity in head and neck cancer treated with radiotherapy plus cetuximab}, author={Carmen Pe{\~n}a Mu{\~n}oz and Miguel Angel Araque Caballero and S. Lokman Hakim and Eug{\`e}nia Verger and Juan Jos{\'e} Grau}, journal={European Archives of Oto-Rhino-Laryngology}, year={2015}, volume={273}, pages={2193-2199} }