Influence of alcohol on the release of tramadol from 24-h controlled-release formulations during in vitro dissolution experiments.

@article{Traynor2008InfluenceOA,
  title={Influence of alcohol on the release of tramadol from 24-h controlled-release formulations during in vitro dissolution experiments.},
  author={Matthew J. Traynor and Marc B. Brown and Ananth Sekher Pannala and Paulo Beck and Gary P. Martin},
  journal={Drug development and industrial pharmacy},
  year={2008},
  volume={34 8},
  pages={885-9}
}
Recent warnings by regulatory bodies and a product recall by the FDA have generated much interest in the area of dose dumping from controlled-release opioid analgesic formulations when coingested with alcohol. It was the aim of this study to address this issue and in doing so, gain understanding on how alcohol-induced effects may be avoided. In this study, tramadol release from Ultram ER tablets and T-long capsules was significantly increased in the presence of ethanol. Conversely, a decrease… CONTINUE READING

From This Paper

Topics from this paper.
15 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

Similar Papers

Loading similar papers…