Influence of albumin on the net sinusoidal efflux of the organic anion dibromosulfophthalein from rat liver.

Besides being excreted into bile, several anionic drugs and anionic drug conjugates are excreted from liver into plasma by a carrier-mediated process (sinusoidal efflux). In the study presented here, we investigated the influence of albumin on the net sinusoidal efflux of an organic anion from isolated perfused liver, with net sinusoidal efflux defined as… CONTINUE READING