Influence of agmatine in adaptation of cAMP signal transduction system of opiate receptors.

Abstract

AIM To observe attenuative effects of agmatine on opiate desensitization and substance dependence. METHODS Guanosine 5'-O-(3-[35S] thiotriphosphate) ([35S]GTTP) binding and cellular cyclic AMP (cAMP) level were determined by radioligand binding assay and radioimmunoassay in NG108-15 cells, respectively. RESULTS Agmatine increased stimulative action of… (More)

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Cite this paper

@article{Li1999InfluenceOA, title={Influence of agmatine in adaptation of cAMP signal transduction system of opiate receptors.}, author={J. Li and Xuemin Li and Gang Pei and Bin Qin}, journal={Zhongguo yao li xue bao = Acta pharmacologica Sinica}, year={1999}, volume={20 7}, pages={592-6} }