Influence of age on the cardiovascular response during graded haemorrhage in anaesthetized rats

  title={Influence of age on the cardiovascular response during graded haemorrhage in anaesthetized rats},
  author={Andrej Bani{\vc} and Gisli H. Sigurdsson and Anthony M. Wheatley},
  journal={Research in Experimental Medicine},
The present study was designed to follow the cardiovascular response to graded haemorrhage in two groups of adult rats of different ages. Group A (n=10) had a mean body weight (bwt) of 655 g (50 weeks old) and group B (n=10) had a mean bwt of 250 g (12 weeks old). After induction of anaesthesia, the carotid artery was cannulated for continuous intra-arterial blood pressure monitoring and for controlled haemorrhage. Five per cent of the total blood volume (TBV) was removed every 15 min until a… 
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