Influence of age on the cardiovascular response during graded haemorrhage in anaesthetized rats

@article{Bani1993InfluenceOA,
  title={Influence of age on the cardiovascular response during graded haemorrhage in anaesthetized rats},
  author={Andrej Bani{\vc} and Gisli H. Sigurdsson and Anthony M. Wheatley},
  journal={Research in Experimental Medicine},
  year={1993},
  volume={193},
  pages={315-321}
}
The present study was designed to follow the cardiovascular response to graded haemorrhage in two groups of adult rats of different ages. Group A (n=10) had a mean body weight (bwt) of 655 g (50 weeks old) and group B (n=10) had a mean bwt of 250 g (12 weeks old). After induction of anaesthesia, the carotid artery was cannulated for continuous intra-arterial blood pressure monitoring and for controlled haemorrhage. Five per cent of the total blood volume (TBV) was removed every 15 min until a… 
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References

SHOWING 1-10 OF 30 REFERENCES

A simple survival model of volume-controlled hemorrhagic shock in awake rats.

Dying pattern in volume-controlled hemorrhagic shock in awake rats.

Attenuation of the acute cardiovascular responses to haemorrhage by tissue injury in the conscious rat.

It is concluded that tissue injury can modify the cardiovascular response to a severe haemorrhage, possibly by interacting with the reflex effects of stimulating cardiac C fibre afferents.

Anesthetic Influences on Regional Hemodynamics in Normal and Hemorrhaged Rats

Overall results suggested that, in terms of cardiac output and regional blood flows, ketamine approximates the awake state most closely in normovolemic animals, whereas isoflurane anesthesia is most like the awake condition after hemorrhage.

Diminished Inotropic Response of Aged Myocardium to Catecholamines

It is concluded that the intrinsic inotropic response to catecholamines is diminished in the aged myocardium and this finding does not appear to result from differences in tachyphylaxis, tissue uptake of catechlamines, or the ability of the contractile proteins to respond to increasing concentrations of calcium but instead may result from a decreased ability of ctcholamines to increase the intracellular calcium available for contraction.

Experimental production of hemorrhagic shock in the rat.

The standardized method for the production of hypovolemic shock in the rat is useful in quantitative evaluation of the influence of various physical and chemical agents in the production and treatment of shock.

Sympathetic response to exercise in various tissues with advancing age.

It was concluded that, in response to exercise stress, the older animals generally demonstrated a higher NEt (reflecting elevated sympathetic activity) perhaps because of a decreased adrenergic receptor sensitivity and/or responsiveness.

A decline in myocardial and hepatic norepinephrine turnover with age in Fischer 344 rats.

It was concluded that the reduced catecholamine content seen in various tissues with advancing age can be explained, in part, by a diminished ability for catechlamine synthesis.

Effect of limb ischaemia on blood pressure and the blood pressure-heart rate reflex in the rat.

The effects of bilateral hind-limb ischaemic on blood pressure and on the blood pressure-heart rate reflex have been studied in the rat and it is suggested that neurones in the defence area may be activated by limb ischaemia.