Influence of age and caloric restriction on expression of hepatic genes for xenobiotic and oxygen metabolizing enzymes in the mouse.

Abstract

The influence of age and life-span-prolonging caloric restriction on the expression of hepatic genes for xenobiotic and activated oxygen metabolism was investigated in female C3B10RF1 mice, a long-lived hybrid strain. Animals were fed either ad libitum, or diets reduced 20% or 52% in total calories but approximately unchanged in total protein, vitamins, and… (More)

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