Influence of age, gender, and race on pharmacokinetics, pharmacodynamics, and safety of fesoterodine.

@article{Malhotra2009InfluenceOA,
  title={Influence of age, gender, and race on pharmacokinetics, pharmacodynamics, and safety of fesoterodine.},
  author={Bimal K. Malhotra and Nolan Wood and Richard Sachse},
  journal={International journal of clinical pharmacology and therapeutics},
  year={2009},
  volume={47 9},
  pages={570-8}
}
OBJECTIVE Fesoterodine, a new antimuscarinic agent for overactive bladder, undergoes immediate and extensive hydrolysis by nonspecific esterases to 5-hydroxymethyl tolterodine (5-HMT), the metabolite principally responsible for its antimuscarinic activity. Formation of 5-HMT does not require cytochrome P450 (CYP)-mediated metabolism, but its further metabolism and inactivation involves CYP3A4 and CYP2D6 isoenzymes. Subject age, gender, and race can play a key role in inter-subject variability… CONTINUE READING

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