Influence of acquired β-lactamases on the evolution of spontaneous carbapenem resistance in Escherichia coli.

@article{Adler2013InfluenceOA,
  title={Influence of acquired β-lactamases on the evolution of spontaneous carbapenem resistance in Escherichia coli.},
  author={Marlen Adler and Mehreen Anjum and Dan I Andersson and Linus Sandegren},
  journal={The Journal of antimicrobial chemotherapy},
  year={2013},
  volume={68 1},
  pages={51-9}
}
OBJECTIVES To investigate the influence of plasmid-borne β-lactamases on the evolution of spontaneous carbapenem resistance in Escherichia coli and the fitness costs associated with resistance. METHODS Stepwise selection of carbapenem-resistant mutants with or without the extended-spectrum β-lactamase (ESBL)-encoding plasmid pUUH239.2 was performed. Mutation rates and mutational pathways to resistance were determined. In vitro-selected and constructed mutants were characterized regarding the… CONTINUE READING
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