Influence of acidosis on AMP deaminase activity in contracting fast-twitch muscle.

@article{Dudley1985InfluenceOA,
  title={Influence of acidosis on AMP deaminase activity in contracting fast-twitch muscle.},
  author={Gary A. Dudley and Ronald L. Terjung},
  journal={The American journal of physiology},
  year={1985},
  volume={248 1 Pt 1},
  pages={C43-50}
}
The rate of AMP deamination to IMP and NH4, by the action of AMP deaminase, is increased in vitro by acidosis and elevations in [AMP] and [ADP]. We evaluated the influence of acidosis on the activity of AMP deaminase in contracting muscle (5 Hz) by relating the time course of IMP and NH4 production to lactate-induced acidosis in low-oxidative, fast-twitch white (FTW) and high-oxidative, fast-twitch red (FTR) muscle of the rat. Cellular acidosis was modified by controlling lactic acid… CONTINUE READING

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