Influence of a specific 5-HT3 antagonist on carrageenan-induced hyperalgesia in rats

@article{Eschalier1989InfluenceOA,
  title={Influence of a specific 5-HT3 antagonist on carrageenan-induced hyperalgesia in rats},
  author={Alain Eschalier and Val{\'e}rie Kayser and Gis{\'e}le Guilbaud},
  journal={Pain},
  year={1989},
  volume={36},
  pages={249-255}
}
The effect of ICS 205-930 (ICS), a specific 5-HT3 antagonist, was studied on carrageenan (CAR)-induced rat paw inflammation to assess the involvement of endogenous released serotonin (5-HT) in the observed hyperalgesia. Studies were performed using a behavioural test, measuring the threshold stimulus necessary to elicit vocalization by gradually increasing pressure applied to the paw. When administered (s.c., in the CAR-injected paw) either 20 min before, simultaneously or 20 min after CAR, ICS… CONTINUE READING

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