Influence of a pre-stimulation with chronic low-dose UVB on stress response mechanisms in human skin fibroblasts

Abstract

Exposure to solar ultraviolet type B (UVB), through the induction of cyclobutane pyrimidine dimer (CPD), is the major risk factor for cutaneous cancer. Cells respond to UV-induced CPD by triggering the DNA damage response (DDR) responsible for signaling DNA repair, programmed cell death and cell cycle arrest. Underlying mechanisms implicated in the DDR have… (More)
DOI: 10.1371/journal.pone.0173740

Topics

8 Figures and Tables

Slides referencing similar topics