Influence of a benzoquinolizinyl derivative on serum and hepatic alkaline phosphatase activity in the dog and rat.

@article{Leeling1975InfluenceOA,
  title={Influence of a benzoquinolizinyl derivative on serum and hepatic alkaline phosphatase activity in the dog and rat.},
  author={J L Leeling and R E Hartnagel and J J Bare and Eug{\'e}nia Fonseca and Petra Kraus and R L Kowalski},
  journal={Toxicology},
  year={1975},
  volume={4 2},
  pages={223-9}
}
Oral administration of 100 mg/kg of TR2379, N-(1,3,4,6,7-hexahydro-11bH-benzo[a]quinolizin-2-yl) propionanilide hydrochloride, for 20--29 days to 6 dogs resulted in significant elevations of alkaline phosphatase (AP) activity in serum and in liver microsomes. Results of biochemical and histochemical experiments revealed that the liver was the sole source of the increased AP activity but there was no evidence of liver damage. The subchronic (7-35 day) p.o. administration of TR2379 at 820 mg/kg… CONTINUE READING

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