Influence of a Streptomyces lividans SecG functional analogue on protein secretion.

  title={Influence of a Streptomyces lividans SecG functional analogue on protein secretion.},
  author={Carmen Palomino and Rafael P. Mellado},
  journal={International microbiology : the official journal of the Spanish Society for Microbiology},
  volume={11 1},
The membrane protein complex translocase mediates the translocation of bacterial proteins. In this complex, the SecY, SecE, and SecG proteins constitute an integral membrane domain. Sequence comparison revealed a potential secG-like gene in the gram-positive soil bacterium Streptomyces lividans. Chromosomal deletion of this gene resulted in a sporulation defect and an overall deficiency in secretion. The SecG-depleted strain was able to overproduce and secrete alpha-amylase, but the appearance… CONTINUE READING


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The importance of the Tat-dependent protein secretion pathway in Streptomyces as revealed by phenotypic changes in tat deletion mutants and genome analysis

  • K Schaerlaekens, L Van Mellalert, E Lammertyn, N Geukens, J Anné
  • Microbiology
  • 2004
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