Influence of XRCC1 Genetic Polymorphisms on Ionizing Radiation-Induced DNA Damage and Repair

@inproceedings{Sterpone2010InfluenceOX,
  title={Influence of XRCC1 Genetic Polymorphisms on Ionizing Radiation-Induced DNA Damage and Repair},
  author={Silvia Sterpone and Renata Cozzi},
  booktitle={Journal of nucleic acids},
  year={2010}
}
It is well known that ionizing radiation (IR) can damage DNA through a direct action, producing single- and double-strand breaks on DNA double helix, as well as an indirect effect by generating oxygen reactive species in the cells. Mammals have evolved several and distinct DNA repair pathways in order to maintain genomic stability and avoid tumour cell transformation. This review reports important data showing a huge interindividual variability on sensitivity to IR and in susceptibility to… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 46 references

Base excision repair: the long and short of it

A. B. Robertson, A. Klungland, T. Rognes, I. Leiros
Cellular and Molecular Life Sciences, vol. 66, no. 6, pp. 981–993, 2009. • 2009
View 1 Excerpt

Mismatched repair: variations on a theme

C. Kunz, Y. Saito, P. Schär
Cellular and Molecular Life Sciences, vol. 66, no. 6, pp. 1021–1038, 2009. • 2009
View 1 Excerpt

Nucleotide excision repair: variations on versatility

T. Nouspikel
Cellular and Molecular Life Sciences, vol. 66, no. 6, pp. 994–1009, 2009. • 2009
View 1 Excerpt

Similar Papers

Loading similar papers…