Influence of Uridine Diphosphate‐Glucuronyltransferase 2B7 (UGT2B7) Variants on Postoperative Buprenorphine Analgesia

@article{Sastre2015InfluenceOU,
  title={Influence of Uridine Diphosphate‐Glucuronyltransferase 2B7 (UGT2B7) Variants on Postoperative Buprenorphine Analgesia},
  author={Jos{\'e} A Sastre and Gonzalo M Varela and M{\'o}nica L{\'o}pez and Clemente Muriel and Rogelio Gonz{\'a}lez-Sarmiento},
  journal={Pain Practice},
  year={2015},
  volume={15}
}
Genetic factors are known to influence individual differences in pain and sensitivity to analgesics. Different genetic polymorphisms in opioid‐metabolizing enzymes that can affect the analgesic response to opioids have been proposed. This study investigates a possible difference in the response to postoperative buprenorphine analgesia related to the presence of different isoforms (cytosine or thymine substitution at nucleotide 802) of UGT2B7 gene. 
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