Influence of Transforming Growth Factor-β1 Gene Polymorphism at Codon 10 on the Development of Cirrhosis in Chronic Hepatitis B Virus Carriers

@inproceedings{Yu2010InfluenceOT,
  title={Influence of Transforming Growth Factor-β1 Gene Polymorphism at Codon 10 on the Development of Cirrhosis in Chronic Hepatitis B Virus Carriers},
  author={Sang Kyun Yu and Oh Sang Kwon and Hyuk Sang Jung and Kyung Suk Bae and Kwang An Kwon and Yu Kyung Kim and Yun Kim and Ju Hyun Kim},
  booktitle={Journal of Korean medical science},
  year={2010}
}
Transforming growth factor (TGF)-beta1 is a key cytokine producing extracellular matrix. We evaluated the effect of TGF-beta1 gene polymorphism at codon 10 on the development of cirrhosis in patients with chronic hepatitis B. One hundred seventy eight patients with chronic hepatitis (CH, n=57) or liver cirrhosis (LC, n=121), who had HBsAg and were over 50 yr old, were enrolled. The genotypes were determined by single strand conformation polymorphism. There were no significant differences in age… CONTINUE READING